{"id":102,"date":"2021-08-07T14:05:22","date_gmt":"2021-08-07T14:05:22","guid":{"rendered":"https:\/\/people.utm.my\/ikhwanjamal\/?page_id=102"},"modified":"2022-02-08T02:28:13","modified_gmt":"2022-02-08T02:28:13","slug":"research","status":"publish","type":"page","link":"https:\/\/people.utm.my\/ikhwanjamal\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”3.22″ animation_style=”slide” animation_direction=”top” animation_intensity_slide=”2%” animation_starting_opacity=”100%” global_colors_info=”{}”][et_pb_fullwidth_header title=”Research Highlights” content_max_width=”700px” _builder_version=”4.10.8″ title_font=”Lato||||||||” title_font_size=”60px” title_line_height=”1.2em” content_font=”||||||||” content_font_size=”20px” content_line_height=”1.8em” background_color=”rgba(255, 255, 255, 0)” use_background_color_gradient=”on” background_color_gradient_start=”rgba(0,0,0,0.75)” background_color_gradient_end=”rgba(0,0,0,0)” background_color_gradient_direction=”90deg” background_color_gradient_overlays_image=”on” background_image=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/graphene-3193185_1920-1.jpeg” custom_button_one=”on” button_one_text_size=”18px” button_one_bg_color=”#02d002″ button_one_border_width=”8px” button_one_border_color=”#02d002″ button_one_border_radius=”0px” button_one_letter_spacing=”1px” button_one_font=”Lato|700|||||||” button_one_use_icon=”off” custom_button_two=”on” button_two_text_size=”18px” button_two_text_color=”#353740″ button_two_bg_color=”#ffffff” button_two_border_width=”8px” button_two_border_color=”#ffffff” button_two_border_radius=”0px” button_two_letter_spacing=”1px” button_two_font=”Lato|700|||||||” button_two_use_icon=”off” custom_margin=”|||” custom_padding=”6.3%||5.8%|||” button_one_letter_spacing_hover=”1px” button_two_letter_spacing_hover=”1px” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”1px” button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”1px” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Sponsors Section” _builder_version=”3.22″ custom_padding=”50px||50px|||” global_colors_info=”{}”][et_pb_row admin_label=”Blog Title Area” _builder_version=”3.25″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”3.27.4″ text_font=”||||||||” header_font=”||||||||” header_2_font=”Lato||||||||” header_2_font_size=”36px” header_2_line_height=”1.5em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_padding=”|||” animation_direction=”left” global_colors_info=”{}”]<\/p>\n

Current Research<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature Section” _builder_version=”3.22″ custom_padding=”31px||0px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ admin_label=”Feature 02 Area” _builder_version=”3.25″ background_color=”#e55039″ custom_margin=”|auto|31px|auto||” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”5%|5%|5%|5%” custom_padding_tablet=”0px|0px|0px|0px” custom_padding_last_edited=”off|desktop” global_colors_info=”{}” padding_tablet=”0px|0px|0px|0px” padding_last_edited=”off|desktop” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.10.8″ text_font=”||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Lato||||||||” header_2_font_size=”36px” header_2_line_height=”1.5em” background_layout=”dark” module_alignment=”center” custom_margin=”||15px|” custom_padding=”||2px|||” animation_direction=”left” locked=”off” global_colors_info=”{}”]<\/p>\n

Synthesis of Electrospun nanofibres for application in drug delivery and tissue engineering<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.10.8″ text_font=”||||||||” text_line_height=”1.8em” header_font=”||||||||” background_layout=”dark” max_width=”525px” module_alignment=”left” animation_style=”fade” animation_direction=”left” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

\u201cThe electrospinning process affords the opportunity to engineer scaffolds with micro to nanoscale topography and high porosity similar to the natural extracellular matrix (ECM). The inherently high surface-to-volume ratio of electrospun scaffolds can enhance cell attachment, drug loading, and mass transfer properties. Various materials can be electrospun including biodegradable, non-degradable, and natural materials. Electrospun fibers can be oriented or arranged randomly, giving control over both the bulk mechanical properties and the biological response to the scaffold. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, and RNA can be incorporated into electrospun scaffolds. Suspensions containing living cells have even been electrospun successfully. The applications of electrospinning in tissue engineering and drug delivery are nearly limitless\u201d [2]. Currently, I am investigating the potential of incorporating CA\/PCL with Paclitaxel\/Temolozomide drug to cure cancer and CA\/PCL with\u00a0<\/span>Aquilaria Malaccensis<\/em>\u00a0for anti-cancer properties study.<\/span><\/p>\n

[1] Sill TJ, Von Recum HA. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008 May 1;29(13):1989-2006.<\/p>\n

[2] Faki R, Gursoy O, Yilmaz Y. Effect of electrospinning process on total antioxidant activity of electrospun nanofibers containing grape seed extract. Open Chemistry. 2019 Jan 1;17(1):912-8<\/p>\n

[3] Weng L, Xie J. Smart electrospun nanofibers for controlled drug release: recent advances and new perspectives. Current pharmaceutical design. 2015 May 1;21(15):1944-59.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/graphic_j_chem-2019-0098_fig_001.jpeg” title_text=”graphic_j_chem-2019-0098_fig_001″ align=”center” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ custom_margin=”-40px||-40px|” custom_padding=”|40px||” animation_style=”zoom” animation_direction=”left” animation_starting_opacity=”100%” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/Fig-2-Various-applications-of-electrospun-nanofibers-in-biomedical-re-search.png” title_text=”Fig-2-Various-applications-of-electrospun-nanofibers-in-biomedical-re-search” _builder_version=”4.10.8″ _module_preset=”default” transform_scale=”96%|96%” custom_margin=”60px||||false|false” animation_style=”zoom” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Sponsors Section” _builder_version=”3.22″ custom_padding=”31px||31px|||” global_colors_info=”{}”][et_pb_row admin_label=”Blog Title Area” _builder_version=”3.25″ locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”3.27.4″ text_font=”||||||||” header_font=”||||||||” header_2_font=”Lato||||||||” header_2_font_size=”36px” header_2_line_height=”1.5em” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_padding=”|||” animation_direction=”left” locked=”off” global_colors_info=”{}”]<\/p>\n

Previous Research<\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature Section” _builder_version=”3.22″ custom_padding=”30px||4px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ admin_label=”Feature 02 Area” _builder_version=”4.10.8″ background_color=”#e55039″ custom_margin=”||80px|” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”5%|5%|5%|5%” custom_padding_tablet=”0px|0px|0px|0px” custom_padding_last_edited=”off|desktop” global_colors_info=”{}” padding_tablet=”0px|0px|0px|0px” padding_last_edited=”off|desktop” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”4.10.8″ text_font=”||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Lato||||||||” header_2_font_size=”36px” header_2_line_height=”1.5em” background_layout=”dark” module_alignment=”center” custom_margin=”||15px|” custom_padding=”|||” animation_direction=”left” locked=”off” global_colors_info=”{}”]<\/p>\n

The Golgi Stress Response and unfolded protein response<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.10.8″ text_font=”||||||||” text_line_height=”1.8em” header_font=”||||||||” background_layout=”dark” max_width=”525px” module_alignment=”left” animation_style=”fade” animation_direction=”left” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

Eukaryotic cells have various organelles, including the ER and the Golgi apparatus. The amount of each organelle is tightly regulated in accordance with cellular demands, which is called organelle autoregulation. Clarification of the molecular mechanism of the organelle autoregulation is one of the fundamental issues in cell biology.<\/span><\/p>\n

Prof. Yoshida\u2019s group has been analyzing the autoregulatory mechanism of the Golgi apparatus, that is, the Golgi stress response. When cells increase the synthesis of secretory or membrane proteins, the functional capacity of the Golgi becomes insufficient (Golgi stress), leading to activation of the Golgi stress response in order to augment the capacity of the Golgi. The fundamentals of the Golgi stress response mechanism are simple, consisting of: (i) a sensor molecule that detects insufficiency of Golgi function; (ii) a transcription factor that induces the transcription of Golgi-related genes; (iii) a transcriptional enhancer element to which the transcription factor binds; and (iv) target genes that encode Golgi-related proteins such as glycosylation enzymes and vesicular transport components.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/EmbeddedImage-624×633-1.png” title_text=”EmbeddedImage-624×633″ force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ transform_scale=”76%|76%” custom_margin=”-40px||-40px||true|” custom_padding=”|40px||” animation_style=”zoom” animation_direction=”left” animation_starting_opacity=”100%” box_shadow_style=”preset1″ box_shadow_blur=”80px” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/EmbeddedImage-1-1-1024×585-1.png” title_text=”EmbeddedImage-1-1-1024×585″ _builder_version=”4.10.8″ _module_preset=”default” transform_scale=”114%|114%” custom_margin=”21px||||false|false” custom_padding=”30px||||false|false” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Feature Section” _builder_version=”3.22″ custom_padding=”25px||29px|||” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ admin_label=”Feature 02 Area” _builder_version=”3.25″ background_color=”#e55039″ custom_margin=”|auto|30px|auto||” custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”5%|5%|5%|5%” custom_padding_tablet=”0px|0px|0px|0px” custom_padding_last_edited=”off|desktop” global_colors_info=”{}” padding_tablet=”0px|0px|0px|0px” padding_last_edited=”off|desktop” custom_padding__hover=”|||”][et_pb_text admin_label=”Title” _builder_version=”3.27.4″ text_font=”||||||||” text_font_size=”16px” text_line_height=”1.8em” header_font=”||||||||” header_2_font=”Lato||||||||” header_2_font_size=”36px” header_2_line_height=”1.5em” background_layout=”dark” module_alignment=”center” custom_margin=”||15px|” custom_padding=”|||” animation_direction=”left” locked=”off” global_colors_info=”{}”]<\/p>\n

Metal Injection Moulding of Porous Ti-6Al-4V for Biomedical Implantation<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.10.8″ text_font=”||||||||” text_line_height=”1.8em” header_font=”||||||||” background_layout=”dark” max_width=”525px” module_alignment=”left” custom_padding=”||0px|||” animation_style=”fade” animation_direction=”left” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”]<\/p>\n

Metal Injection Moulding (MIM) is a promising approach to produce a near-net-shape product of intricate geometry with cost-effective production. There are four main processing steps in MIM which are mixing; injection molding; debinding; and sintering (German & Bose, 1997). To date, numerous studies have been done on implementing MIM to manufacture products for biomedical applications by employing Titanium and its alloy as the main subject. Titanium and its alloys are renowned materials with their biocompatibility, good mechanical properties, and high corrosion resistance. This study was aimed to fabricate porous Ti-6Al-4V structure through MIM technique using palm stearin (PS) binder system. Titanium alloy powder (Ti-6Al-4V) was used to mix with sodium chloride (NaCl) as a space holder and binder components that consists of palm stearin (PS) as a primary binder and polyethylene (PE) as a backbone binder.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/Image-from-Research-_-Ikhwanjamals-academic-adventures-page-4.png” title_text=”Image from Research _ Ikhwanjamal’s academic adventures, page 4″ force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ custom_margin=”-40px||-40px|” custom_padding=”|40px||” animation_style=”slide” animation_direction=”left” animation_intensity_slide=”8%” animation_starting_opacity=”100%” box_shadow_style=”preset1″ box_shadow_blur=”80px” global_colors_info=”{}”][\/et_pb_image][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/Image-from-3Research-_-Ikhwanjamals-academic-adventures-page-4.png” title_text=”Image from 3Research _ Ikhwanjamal’s academic adventures, page 4″ align=”center” _builder_version=”4.10.8″ _module_preset=”default” width=”81%” custom_padding=”78px||||false|false” animation_style=”zoom” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ use_custom_gutter=”on” gutter_width=”1″ specialty=”on” padding_top_1=”0px” padding_bottom_1=”0px” admin_label=”Image Gallery Section” module_class=” et_pb_specialty_fullwidth” _builder_version=”3.22″ inner_width=”100%” inner_width_tablet=”100%” inner_width_phone=”” inner_width_last_edited=”on|desktop” inner_max_width=”100%” inner_max_width_tablet=”100%” inner_max_width_phone=”” inner_max_width_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px” make_fullwidth=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/image.jpg” title_text=”image” show_in_lightbox=”on” use_overlay=”on” overlay_icon_color=”#ffffff” hover_overlay_color=”rgba(0,0,0,0.3)” hover_icon=”%%15%%” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ transform_scale=”68%|68%” custom_margin=”||0px||false|false” animation_style=”zoom” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_spread=”8px” box_shadow_color=”#ffffff” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ specialty_columns=”2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”3.25″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/IMG_6519.jpeg” title_text=”IMG_6519″ show_in_lightbox=”on” use_overlay=”on” overlay_icon_color=”#ffffff” hover_overlay_color=”rgba(0,0,0,0.3)” hover_icon=”%%15%%” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ custom_margin=”|||” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_spread=”8px” box_shadow_color=”#ffffff” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ _builder_version=”3.25″ custom_padding=”0px|0px|0px|0px” global_colors_info=”{}”][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/72E80188-0AD9-4A93-884B-C24FEC125407_1_105_c.jpeg” title_text=”72E80188-0AD9-4A93-884B-C24FEC125407_1_105_c” show_in_lightbox=”on” use_overlay=”on” overlay_icon_color=”#ffffff” hover_overlay_color=”rgba(0,0,0,0.3)” hover_icon=”%%15%%” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ custom_margin=”|||” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_spread=”8px” box_shadow_color=”#ffffff” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column_inner][et_pb_column_inner type=”1_2″ saved_specialty_column_type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/CBEC54AD-7E8F-43D4-856B-B5D29D5E5E6A_1_105_c.jpeg” title_text=”CBEC54AD-7E8F-43D4-856B-B5D29D5E5E6A_1_105_c” show_in_lightbox=”on” use_overlay=”on” overlay_icon_color=”#ffffff” hover_overlay_color=”rgba(0,0,0,0.3)” hover_icon=”%%15%%” force_fullwidth=”on” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.10.8″ custom_margin=”|||” box_shadow_style=”preset7″ box_shadow_horizontal=”0px” box_shadow_vertical=”0px” box_shadow_spread=”8px” box_shadow_color=”#ffffff” locked=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” admin_label=”Call to Action” _builder_version=”3.22″ animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”6%” animation_starting_opacity=”100%” locked=”off” global_colors_info=”{}”][et_pb_fullwidth_header title=”We welcome your generosity. Fund our research today!” button_one_text=”Get Involved” button_one_url=”https:\/\/api.whatsapp.com\/send?phone=60196106905″ button_two_text=”Donate” button_two_url=”https:\/\/drive.google.com\/file\/d\/1–CuTGE5u1z4POaWluJbnFfK8ZR6UOIO\/view?usp=sharing” content_max_width=”800px” _builder_version=”4.10.8″ title_level=”h2″ title_font=”Lato||||||||” title_font_size=”60px” title_line_height=”1.2em” content_font=”||||||||” content_font_size=”20px” content_line_height=”1.8em” background_color=”rgba(255, 255, 255, 0)” use_background_color_gradient=”on” background_color_gradient_start=”rgba(0,0,0,0.75)” background_color_gradient_end=”rgba(0,0,0,0)” background_color_gradient_direction=”90deg” background_color_gradient_overlays_image=”on” background_image=”https:\/\/people.utm.my\/ikhwanjamal\/wp-content\/uploads\/sites\/2596\/2022\/02\/writer-05.jpg” custom_button_one=”on” button_one_text_size=”18px” button_one_bg_color=”#02d002″ button_one_border_width=”8px” button_one_border_color=”#02d002″ button_one_border_radius=”0px” button_one_letter_spacing=”1px” button_one_font=”Lato|700|||||||” button_one_use_icon=”off” custom_button_two=”on” button_two_text_size=”18px” button_two_text_color=”#353740″ button_two_bg_color=”#ffffff” button_two_border_width=”8px” button_two_border_color=”#ffffff” button_two_border_radius=”0px” button_two_letter_spacing=”1px” button_two_font=”Lato|700|||||||” button_two_use_icon=”off” custom_margin=”|||” custom_padding=”8%||8%|” link_option_url_new_window=”on” hover_enabled=”0″ button_one_letter_spacing_hover=”1px” button_two_letter_spacing_hover=”1px” global_colors_info=”{}” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”on” button_one_letter_spacing__hover=”1px” button_two_letter_spacing__hover_enabled=”on” button_two_letter_spacing__hover=”1px” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” sticky_enabled=”0″][\/et_pb_fullwidth_header][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Current ResearchSynthesis of Electrospun nanofibres for application in drug delivery and tissue engineering\u201cThe electrospinning process affords the opportunity to engineer scaffolds with micro to nanoscale topography and high porosity similar to the natural extracellular matrix (ECM). The inherently high surface-to-volume ratio of electrospun scaffolds can enhance cell attachment, drug loading, and mass transfer properties. Various […]<\/p>\n","protected":false},"author":25456,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"\n

<\/p>\n\n\n\n

Current Research<\/h2>\n\n\n\n

Synthesis of Electrospun nanofibres for application in drug delivery and tissue engineering<\/h3>\n\n\n\n
\"\"
Scheme of the electrospinning system with major components [1]<\/figcaption><\/figure>\n\n\n\n

\"The electrospinning process affords the opportunity to engineer scaffolds with micro to nanoscale topography and high porosity similar to the natural extracellular matrix (ECM). The inherently high surface-to-volume ratio of electrospun scaffolds can enhance cell attachment, drug loading, and mass transfer properties. Various materials can be electrospun including biodegradable, non-degradable, and natural materials. Electrospun fibers can be oriented or arranged randomly, giving control over both the bulk mechanical properties and the biological response to the scaffold. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, and RNA can be incorporated into electrospun scaffolds. Suspensions containing living cells have even been electrospun successfully. The applications of electrospinning in tissue engineering and drug delivery are nearly limitless\" [2]. Currently, I am investigating the potential of incorporating CA\/PCL with Paclitaxel\/Temolozomide drug to cure cancer and CA\/PCL with Aquilaria Malaccensis<\/em> for anti-cancer properties study.<\/p>\n\n\n\n

\"\"
Various applications of electrospun nanofibers in biomedical research [3]<\/figcaption><\/figure>\n\n\n\n

[1] Sill TJ, Von Recum HA. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008 May 1;29(13):1989-2006.<\/p>\n\n\n\n

[2] Faki R, Gursoy O, Yilmaz Y. Effect of electrospinning process on total antioxidant activity of electrospun nanofibers containing grape seed extract. Open Chemistry. 2019 Jan 1;17(1):912-8<\/p>\n\n\n\n

[3] Weng L, Xie J. Smart electrospun nanofibers for controlled drug release: recent advances and new perspectives. Current pharmaceutical design. 2015 May 1;21(15):1944-59.<\/p>\n\n\n\n

Previous Research<\/h2>\n\n\n\n

The Golgi Stress Response and unfolded protein response<\/strong><\/h3>\n\n\n\n
\n
\n
\"\"<\/figure><\/div>\n\n\n\n

Eukaryotic cells have various organelles, including the ER and the Golgi apparatus. The amount of each organelle is tightly regulated in accordance with cellular demands, which is called organelle autoregulation. Clarification of the molecular mechanism of the organelle autoregulation is one of the fundamental issues in cell biology.<\/p>\n<\/div>\n<\/div>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Prof. Yoshida's group has been analyzing the autoregulatory mechanism of the Golgi apparatus, that is, the Golgi stress response. When cells increase the synthesis of secretory or membrane proteins, the functional capacity of the Golgi becomes insufficient (Golgi stress), leading to activation of the Golgi stress response in order to augment the capacity of the Golgi. The fundamentals of the Golgi stress response mechanism are simple, consisting of: (i) a sensor molecule that detects insufficiency of Golgi function; (ii) a transcription factor that induces the transcription of Golgi-related genes; (iii) a transcriptional enhancer element to which the transcription factor binds; and (iv) target genes that encode Golgi-related proteins such as glycosylation enzymes and vesicular transport components.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Metal Injection Moulding of Porous Ti-6Al-4V for biomedical implantation<\/h3>\n\n\n\n
\n
\n
\"\"
Shrinkage effect before and after sintering. (a) green part (b) PS and NaCl debound part (c) as-sintered part<\/figcaption><\/figure>\n<\/div>\n\n\n\n
\n
\"\"
Pore formed in the as-sintered product<\/figcaption><\/figure>\n<\/div>\n<\/div>\n\n\n\n

Metal Injection Moulding (MIM) is a promising approach to produce a near-net-shape product of intricate geometry with cost-effective production. There are four main processing steps in MIM which are mixing; injection molding; debinding; and sintering (German & Bose, 1997). To date, numerous studies have been done on implementing MIM to manufacture products for biomedical applications by employing Titanium and its alloy as the main subject. Titanium and its alloys are renowned materials with their biocompatibility, good mechanical properties, and high corrosion resistance. This study was aimed to fabricate porous Ti-6Al-4V structure through MIM technique using palm stearin (PS) binder system. Titanium alloy powder (Ti-6Al-4V) was used to mix with sodium chloride (NaCl) as a space holder and binder components that consists of palm stearin (PS) as a primary binder and polyethylene (PE) as a backbone binder.<\/p>\n","_et_gb_content_width":"","footnotes":""},"class_list":["post-102","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/pages\/102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/users\/25456"}],"replies":[{"embeddable":true,"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/comments?post=102"}],"version-history":[{"count":27,"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/pages\/102\/revisions"}],"predecessor-version":[{"id":1224,"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/pages\/102\/revisions\/1224"}],"wp:attachment":[{"href":"https:\/\/people.utm.my\/ikhwanjamal\/wp-json\/wp\/v2\/media?parent=102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}