Citation

S Azmi, SIA Razak, MRA Kadir, N Iqbal, R Hassan… – Soft Materials, 2016

Abstract

This work reports the reinforcement of poly(vinyl alcohol) (PVA) hydrogel with halloysite nanotubes (HNT) as potential biomedical materials. The nanocomposite hydrogel was prepared using the facile and harmless process of freeze-thawing. Mechanical properties of the hydrogels were optimum at 2 wt% of HNT loading. Morphological and topographic analysis of the PVA/HNT hydrogel revealed excellent filler dispersion and smoothing of surface due to good compatibility between the components. Immersion of the PVA/HNT hydrogel in simulated body fluid for 7 days resulted in the formation of fully covered apatite layers on the surface. This is a good indication of bioactivity for artificial cartilage material.

Taylor & Francis Online

Citation

Abd Razak, S. I., Wahab, I. F.,

Abstract

This paper reports for the first time the reinforcement of kappa-carrageenan (kCRG) with clay of halloysite nanotubes (HNT) as potential biomedical materials. The bionanocomposite film (kCRG/HNT) were successfully prepared having optimum tensile properties at 3%wt% of HNT. Morphological and surface analysis of the nanocomposite revealed excellent film formation and increase in surface roughness. Immersion of film is stimulated body fluid for 7 days resulted in growth of hydroxyl apatite particles with Ca/P ratio of 1.68. This is a good indication of bioactivity for possible template in bone tissue engineering. Swelling and methylene blue release experiment indicated possible drug delivery application due to stability of the kCRG matrix up to more than 20 days and delay release of model drug, respectively. This bioresource nanocomposite film has potential as a suitable biomedical material that requires mechanical integrity, bioactivity and drug released.

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