Ultimately, we can do chemical synthesis. A chemist comes to us and says, “Look, I want a molecule that has the atoms arranged thus and so; make me that molecule.” The chemist does a mysterious thing when he wants to make a molecule. He sees that it has got that ring, so he mixes this and that, and he shakes it, and he fiddles around. And, at the end of a difficult process, he usually does succeed in synthesizing what he wants.
– Richard Feynman (Plenty of Room at the Bottom, 1959)