Molecular Docking and Recent Advances in the Design and Development of Cholinesterase Inhibitor Scaffolds: Coumarin Hybrids
By:
Hasan, AH (Hasan, Aso Hameed)
[ 1,2 ] ;
Amran, SI (Amran, Syazwani Itri)
[ 3 ] ;
Hussain, FHS (Hussain, Faiq Hama Saeed)
[ 4 ] ;
Jaff, BA (Jaff, Baram Ahmed)
[ 5 ] ;
Jamalis, J (Jamalis, Joazaizulfazli)
[ 1 ]
[ 1 ] Univ Teknol Malaysia, Fac Sci, Dept Chem, Johor Baharu 81310, Johor, Malaysia
[ 2 ] Univ Garmian Kalar, Coll Sci, Dept Chem, Kalar, Kurdistan Regio, Iraq
[ 3 ] Univ Teknol Malaysia, Fac Sci, Dept Biosci, Johor Baharu 81310, Johor, Malaysia
[ 4 ] Tishk Int Univ, Res Ctr, Erbil, Kurdistan Regio, Iraq
[ 5 ] Charmo Univ, Charmo Res Ctr, Chem Dept, Chamchamal 46023, Kurdistan Regio, Iraq
E-mail Address:joazaizulfazli@utm.my
Abstract
Alzheimer is a deadly neurodegenerative disease that commonly attacks elderly people around the world. Therefore, this disease has drawn attention among the researchers to find new potent drugs to treat Alzheimer disease (AD) more efficiently. Coumarin containing scaffold is a potential AD agent. Coumarin hybrids are frequently used as a template to design novel therapeutic agent for the treatment of AD, which are designed based on using molecular docking. As a result of docking studies shown that coumarin cores can occupy PAS by making extensive hydrophobic interactions with the residues in that region (mainly Trp279, Tyr70, Tyr121, Asp72, Phe290, Trp84, Phe330). The present review compiles research literature on the recent design strategies of coumarin hybrids with anti-Alzheimer’s activities and outlined docking studies.
Keywords
Author Keywords:
Alzheimer disease;
Cholinesterase inhibitors;
Coumarin;
Molecular docking
KeyWords Plus:
BETA-AMYLOID AGGREGATION;
MONOAMINE-OXIDASE B;
ALZHEIMERS-DISEASE;
ACETYLCHOLINESTERASE INHIBITORS;
BIOLOGICAL EVALUATION;
KNOEVENAGEL CONDENSATION;
OXIDATIVE STRESS;
IN-VITRO;
2H-CHROMEN-2-ONE DERIVATIVES;
MULTIFUNCTIONAL AGENTS
CHEMISTRYSELECT
Volume: 4
Issue: 48
Pages: 14140-14156
DOI: 10.1002/slct.201903607
Published: DEC 30 2019
Document Type:Review
CHEMISTRYSELECT
Impact Factor
1.811 1.835
2019 5 year
JCR® Category Rank in Category Quartile in Category
CHEMISTRY, MULTIDISCIPLINARY 111 of 177 Q3
Data from the 2019 edition of Journal Citation Reports
Publisher WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
ISSN: 2365-6549
Research Domain Chemistry
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