Synthesis, characterization, in silico and antifungal studies of thiazolidine analogues
Abid, F.M.A.a, Jamalis, J.a, Chander, S.b, Wahab, R.A.a, Bhagwat, D.P.b, Sankaranarayanan, M.c
- aDepartment of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor Bahru, Johor 81310, Malaysia
- bSchool of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Himachal Pradesh, Solan 174103, India
- cMedicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Rajasthan, Pilani 333031, India
Abstract
A series of sixteen novel heterocyclic thiazolidine derivatives (3a-p) was synthesized upon reaction of L-cysteine with different substituted benzaldehyde. The synthesized compounds were extensively characterized by IR, 1H and 13C NMR spectral analysis. All compounds were evaluated for their anti-fungal activity against Candida albicans and Aspergillus niger using fluconazole as reference drug. The assay revealed that, compound 3k showed significant activity (14 mm ZOI, 64 µg/mL IC50 and 15 mm ZOI, >32 µg/mL IC50) against C. albicans and A. niger, respectively. © 2019
ISSN: 24058300
Source Type: Journal
Original language: English
DOI: 10.1016/j.cdc.2019.100219
Document Type: Data Paper
Publisher: Elsevier B.V.
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